Drosophila Apoptosis and Bcl-2 Genes
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چکیده
منابع مشابه
Drosophila Apoptosis and Bcl-2 Genes
(Igaki et al., 2000) unveils the long anticipated, missing piece of the apoptosome in flies. On page 703 in this issue, in a paper by Colussi et al., Ku-mur, Richardson, and colleagues characterize the first Drosophila members of the Bcl-2 gene family whose function is important for programmed cell death (PCD). The founding member of this gene family was identified as the proto-oncogene upregul...
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Other names: BAM, BIM, BIM-alpha6, BIM-beta6, BIM-beta7, BOD, BimEL, BimL HGNC (Hugo): BCL2L11 Location: 2q13 Local order: According to GeneLoc and NCBI Map Viewer, genes flanking BCL2L11 in plus strand direction are: ACOXL 2q13 (acyl-Coenzyme A oxidase-like); PAFAH1P2 2q13 (platelet-activating factor acetylhydrolase, isoform Ib, pseudogene 2). Note: BCL2L11/BIM is a BH3-only protein from the B...
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The bcl-2 gene provides a window on the basic cellular machinery of apoptosis or programmed cell death, a process involved in virtually all biologic events in multicellular organisms, but particularly relevant to neoplasia and development. bcl-2 gene function supports cell survival and appears to lie at a nodal point in pathways leading to activation or execution of apoptosis. Carcinogenesis ma...
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Bcl-2 family proteins play a central role in regulating apoptosis. We previously reported that human Bcl-rambo, also termed BCL2L13, localized to mitochondria and induced apoptosis when overexpressed in human embryonic kidney 293T cells. However, the physiological function of Bcl-rambo currently remains unclear. In the present study, human Bcl-rambo was ectopically expressed in Drosophila melan...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2000
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.148.4.625